Similar and distinct mechanisms in the protective processes of upper and lower gastrointestinal tract.

Similar and distinct mechanisms in the protective processes of upper and lower gastrointestinal tract. Curr Pharm Des. 2018 May 15;: Authors: Gyires K, László SB, Lázár B, Zádori ZS Abstract Gastrointestinal (GI) mucosal integrity is based on the balance of aggressive and protective mechanisms. Mucosal damage may occur when the injurious factors become dominant or the mucosal defensive processes are impaired. The main target of the therapy against GI mucosal injury is the reduction of aggressive factors, however, the therapeutic possibilities for stimulation of mucosal defensive process are rather limited. This overview focuses on the gastric and intestinal mucosal protective mechanisms and discusses the main targets that increase protective process and increase the mucosal resistance to injurious stimuli at pre-epithelial, epithelial and sub-epithelial levels. PMID: 29766781 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research