Asymmetric synthesis of α-trifluoromethoxy ketones with a tetrasubstituted α-stereogenic centre via the palladium-catalyzed decarboxylative allylic alkylation of allyl enol carbonates.

Asymmetric synthesis of α-trifluoromethoxy ketones with a tetrasubstituted α-stereogenic centre via the palladium-catalyzed decarboxylative allylic alkylation of allyl enol carbonates.
Chem Commun (Camb). 2018 May 16;:
Authors: Kondo H, Maeno M, Hirano K, Shibata N
Abstract
The palladium-catalyzed asymmetric decarboxylative allylic alkylation of trifluoromethoxy allyl enol carbonates afforded enantioenriched α-trifluoromethoxy allyl ketones that feature a tetrasubstituted α-stereogenic center in excellent yield and high enantioselectivity. The method was further extended to the asymmetric synthesis of α-difluoromethoxy and α-methoxy allyl ketones, which proceeded under similar catalytic conditions.
PMID: 29767203 [PubMed - as supplied by publisher]

Source: Chemical Communications - May 16, 2018 Category: Chemistry Authors: Kondo H, Maeno M, Hirano K, Shibata N Tags: Chem Commun (Camb) Source Type: research