The C-terminal extension landscape of naturally presented HLA-I ligands [Immunology and Inflammation]
HLA-I molecules play a central role in antigen presentation. They typically bind 9- to 12-mer peptides, and their canonical binding mode involves anchor residues at the second and last positions of their ligands. To investigate potential noncanonical binding modes, we collected in-depth and accurate HLA peptidomics datasets covering 54 HLA-I...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Philippe Guillaume, Sarah Picaud, Petra Baumgaertner, Nicole Montandon, Julien Schmidt, Daniel E. Speiser, George Coukos, Michal Bassani-Sternberg, Panagis Filippakopoulos, David Gfeller Tags: Physical Sciences Source Type: research
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