THRT Reduces CVD in Diabetic Nephropathy With Hypothyroidism THRT Reduces CVD in Diabetic Nephropathy With Hypothyroidism

The administration of thyroid hormone replacement therapy may help lower the risk of developing CVD among patients with subclinical hypothyroidism and diabetic nephropathy.Endocrine Practice
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

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This study aims to determine the impact of early surgery and comorbid conditions on the outcomes of NSTIs.MethodsA retrospective cohort study was performed on all subjects presenting with NSTI at an academic medical center between 2005 and 2016. Patients were identified based on ICD codes. Those under the age of 18 or with intraoperative findings not consistent with NSTI diagnosis were excluded.ResultsThere were 115 patients with a confirmed diagnosis of NSTI with a mean age of 55  ± 18 years; 41% were females and 55% were diabetics. Thirty percent of patients underwent early surgery (
Source: European Journal of Trauma and Emergency Surgery - Category: Emergency Medicine Source Type: research
ConclusionsRhabdomyolysis is a rare but serious complication due to lipid-lowering therapy with statins and fibrates. Treating physicians should be aware and patients should be warned to report about muscle symptoms after starting statins or fibrates. Rhabdomyolysis may occur with mild symptoms and signs and may occur later, even after discontinuation of the drug.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Abstract Krüppel-like zinc finger proteins form one of the largest families of transcription factors. They function as key regulators of embryonic development and a wide range of other physiological processes, and are implicated in a variety of pathologies. GLI-similar 1-3 (GLIS1-3) constitute a subfamily of Krüppel-like zinc finger proteins that act either as activators or repressors of gene transcription. GLIS3 plays a critical role in the regulation of multiple biological processes and is a key regulator of pancreatic β cell generation and maturation, insulin gene expression, thyroid hormone bios...
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Tags: Cell Mol Life Sci Source Type: research
ConclusionCombination immunotherapy may be an attractive option for HPV-related small cell head and neck cancers resistant to other treatment modalities and thus warrants further evaluation.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
AbstractPurposeType 1 diabetes mellitus (T1DM) is a disorder of insulin deficiency but with a wide range of hormones simultaneously disturbed. The study was performed to explore relation of free triiodothyronine (FT3) with metabolic control and occurrence of microangiopathic complications.MethodsA total of 266 adult T1DM participants [56% men; 32 (interquartile range, IQR: 25 –39) years and disease duration 13 (IQR: 8–19) years] in euthyroid state with negative history for hypothyroidism were included to the study. Participants were screened for thyroid-stimulating hormone (TSH), free thyroxine (FT4) and FT3. M...
Source: Endocrine - Category: Endocrinology Source Type: research
Conclusion Subclinical hypothyroidism likely have significant effect on insulin resistance as major diabetes risk factors and also cardiovascular disease risk factors such as homocysteine. The direct correlation between HOM-IR with serum homocysteine level indicate the possible role of insulin resistance in elevation of serum homocysteine in SCH patient group.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Prehospital assessment tools for neurological deficits aren’t perfect An approximately 30-year-old male answers the door to let you and your partner into the house you’ve been called to. Hank introduces himself and thanks you for coming, quickly adding that he’s concerned about his mother who’s “acting weird.” Hank tells you he stopped by his mom’s house for lunch and found her using paper plates to heat food on the stove. He stopped her before the plate ignited. His mother seemed confused and so he called 9-1-1. Patient Assessment Margaret, Hank’s 53-year-old mot...
Source: JEMS Patient Care - Category: Emergency Medicine Authors: Tags: Patient Care Cardiac & Resuscitation Columns Source Type: news
Comprehensive Endocrine-Metabolic Evaluation of Patients with Alström Syndrome Compared to BMI-Matched Controls. J Clin Endocrinol Metab. 2018 Apr 27;: Authors: Han JC, Reyes-Capo DP, Liu CY, Reynolds JC, Turkbey E, Turkbey IB, Bryant J, Marshall JD, Naggert JK, Gahl WA, Yanovski JA, Gunay-Aygun M Abstract Background: Alström syndrome (AS), a monogenic form of obesity, is caused by recessive mutations in the centrosome- and basal body-associated gene, ALMS1. AS is characterized by retinal dystrophy, sensory hearing loss, cardiomyopathy, childhood obesity, and metabolic derangements. Obj...
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
AbstractPurpose of ReviewThis review summarizes the recent epidemiologic literature examining environmental exposures and health outcomes in rural, minority populations in the southwestern and mountain west region of the USA identifying areas requiring further data and research.Recent FindingsRecent studies (2012 –2017) in this region have primarily focused on arsenic exposure (n = 10 studies) with similar results reported across populations in this region. Associations between arsenic and cadmium were reported for cardiovascular and kidney disease, type II diabetes, cognitive function, hypothyroidism, an...
Source: Current Epidemiology Reports - Category: Epidemiology Source Type: research
A 15-year-old with type 1 diabetes mellitus and hypothyroidism presents after an episode of shaking and palpitations. What is causing her symptoms?Osmosis
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Med Students Interactive Quiz Source Type: news
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