Congenital tuberculosis after in  vitro fertilization presenting with endobronchial granuloma

Congenital tuberculosis (TB) is a rare and severe presentation of Mycobacterium tuberculosis infection. The infection may be transmitted to the fetus by hematogenous spread from the placenta or by the aspiration or ingestion of contaminated amniotic fluid at delivery. Mortality of congenital TB is very high at 50% of untreated infants and 20% of those receiving therapy. The diagnosis is based on revised criteria by Cantwell. Early diagnosis of congenital TB is challenging because of nonspecific symptoms and poor sensitivity of diagnostic tests such as the tuberculin skin test (TST) and interferon- γ release assay.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Short Communication Source Type: research

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Trends in Elevated Blood Lead Levels Using 5 and 10 µg/dL Levels of Concern Among Refugee Children Resettled in Massachusetts, 1998-2015. Public Health Rep. 2019 Sep 20;:33354919874078 Authors: Geltman PL, Smock L, Cochran J Abstract OBJECTIVES: Refugee children are known to have a high prevalence of elevated blood lead levels (EBLLs). We sought to determine trends in EBLLs among refugee children during an 18-year period and examine relationships between descriptive characteristics and EBLLs by using 10 µg/dL and 5 µg/dL levels of concern. METHODS: We retrospectively evaluated ref...
Source: Public Health Reports - Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research
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Source: Public Health Reports - Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research
We report 1 known false-negative, in a patient who developed disseminated TB on anti-TNF therapy. Indeterminate testing rates were higher at IBD diagnosis than during treatment (10.3% vs 5.3%, P 
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research
Conclusions: Anthropometric, genetic, and dosage characteristics of Mexican patients with TB are an important source of risk for subtherapeutic plasma concentrations of anti-TB drugs. Factors such as lower-than-recommended RMP dose, male patients with TB, and MDR1 3435 genotype, in addition to age group, body mass index, and INH acetylator phenotype based on NAT2 genotype, should be considered during treatment.
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Original Article Source Type: research
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Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Multidrug-resistant tuberculosis (MDR-TB) is a major public health concern in the UK and globally. Treatment is prolonged, more toxic and less effective compared to that for drug susceptible TB. In 2018 and then consolidated in 2019, the World Health Organisation (WHO) published major revisions to guidelines, prioritising the new drug bedaquiline and down-grading the injectable agents (aminoglycosides and polypeptides) which had played a major part in previous guidelines.1,2 Changes were based on meta-analysis data of efficacy, accumulating trial data supporting bedaquiline and ethical concerns regarding the side effect pr...
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
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Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
We report the case of a 10-year-old child treated for latent tuberculosis infection (LTBI) with pyrazinamide (PZA) and levofloxacin after contact with a smear-positive multidrug-resistant tuberculosis adult. Over the course of the treatment, the patient developed a drug-induced fulminant hepatitis attributed to the combination of PZA and levofloxacin. This case highlights the hepatotoxicity of the association of second-line anti-TB treatment in children.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Antimicrobial Reports Source Type: research
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Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Antimicrobial Reports Source Type: research
This retrospective study investigated outcomes among lost to follow-up (LTFU) adolescents and young adults (AYAs: 10–24 years of age) with tuberculosis (TB) registered from 2008 to 2014 in Gaborone, using surveillance data. Of 68 LTFU AYAs, 16 repeated treatment; 8 completed and 6 were again LTFU. Of 4 confirmed deaths, 3 had TB/HIV coinfection. Approaches to improve AYA retention in TB care are needed.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Brief Reports Source Type: research
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