Congenital tuberculosis after in  vitro fertilization presenting with endobronchial granuloma

Congenital tuberculosis (TB) is a rare and severe presentation of Mycobacterium tuberculosis infection. The infection may be transmitted to the fetus by hematogenous spread from the placenta or by the aspiration or ingestion of contaminated amniotic fluid at delivery. Mortality of congenital TB is very high at 50% of untreated infants and 20% of those receiving therapy. The diagnosis is based on revised criteria by Cantwell. Early diagnosis of congenital TB is challenging because of nonspecific symptoms and poor sensitivity of diagnostic tests such as the tuberculin skin test (TST) and interferon- γ release assay.

Source: Pediatrics and Neonatology - April 30, 2018 Category: Perinatology & Neonatology Authors: Elisabetta Venturini, Carlotta Montagnani, Antonio Boldrini, Marco Moroni, Elena Chiappini, Maurizio de Martino, Luisa Galli Tags: Short Communication Source Type: research