JNK1 induces hedgehog signaling from stellate cells to accelerate liver regeneration in mice

The unique ability of mammalian liver to regain mass after tissue loss has revolutionized the treatment and cure of many patients with liver tumors. However, there are limitations to effective regeneration, as hepatic failure may develop after extensive liver resection. This entity, known as the small-for-size syndrome (SFSS), results from an insufficient functional volume of the liver remnant and remains the most frequent cause of death due to liver surgery.[1,2] Two-staged hepatectomies were introduced to reduce the SFSS risk.

Source: Journal of Hepatology - April 27, 2018 Category: Gastroenterology Authors: Magda Langiewicz, Rolf Graf, Bostjan Humar, Pierre A. Clavien Source Type: research