Dosimetry and Radiobiology of Alpha-Particle Emitting Radionuclides.
Dosimetry and Radiobiology of Alpha-Particle Emitting Radionuclides.
Curr Radiopharm. 2018 Apr 26;:
Authors: Sgouros G, Hobbs R, Josefsson A
Abstract
Radiopharmaceutical therapy is a cancer treatment modality by which radiation is delivered directly to targeted tumor cells or to their microenvironment. This makes it possible to deliver highly potent alpha-particle radiation. The short-range and highly potent nature of alpha-particles requires a dosimetry methodology that considers microscale distributions of the alpha-emitting agent. The high energy deposition density along an alpha-particle track causes a spectrum of DNA lesions. The majority of these are irreparable DNA double-stranded breaks. Accordingly the biologic effects of alpha-particles are largely impervious to the adaptive and resistance mechanism that render other therapeutics ineffectual.
PMID: 29697036 [PubMed - as supplied by publisher]
Source: Current Radiopharmaceuticals - Category: Radiology Tags: Curr Radiopharm Source Type: research