112 The IL-31-producing circulating T cells subset represents a unique population of CLA+ CRTH2+ CCR4+ central memory T cells

Recent findings underscore an important role of IL-31/IL-31RA signalling in pruritus. In particular, the clinical efficacy of the IL-31RA-targeting antibody nemolizumab in treating itch in atopic dermatitis (AD) patients emphasized the importance of the IL-31/IL-31RA pathway. Although type 2 memory T cells are considered to be the major source of IL-31 production, the phenotype IL-31-producing T cells is poorly characterized. In the present study, we established a reliable protocol for intracellular IL-31 staining in restimulated T cells and investigated the detailed phenotype of IL-31-producing T cells in AD patients and healthy volunteers.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research