432 Investigating a causal relationship between body mass index and inflammatory skin disease using mendelian randomisation

Psoriasis and atopic dermatitis (AD) are common inflammatory skin diseases reported to be associated with obesity, but the direction(s) of causality remain unclear. Mendelian Randomisation (MR) can be used to test for a causal relationship between a heritable phenotype and a possible clinical outcome. Genetic variants are used as an instrument to investigate causality and this reduces confounding and reverse causality. Our aim was to investigate a possible causal relationship between body mass index (BMI) and psoriasis or AD.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Pathophysiology and Therapeutics Source Type: research