902 Ablation of basophils reduces ILC2-dependent atopic dermatitis-like inflammation in mice overexpressing interleukin-33 in the skin

Interleukin-33 (IL-33) stimulates Th2 cells, basophils, and group 2 innate lymphoid cells (ILC2). We generated a transgenic mouse expressing IL-33 driven by a keratin-14 promoter (IL33Tg) and showed that IL-33 elicits atopic dermatitis (AD)-like inflammation with activation of ILC2 and basophils (Imai Y, PNAS, 2013; Imai Y, Sci Rep, 2017). Previously, we reported that basophils are a major source of IL-4 (Yoshimoto T, Nat immunol, 2009), and recently it was reported that basophils are necessary for the activation of ILC2 in asthma (Motomura Y, Immunity, 2014).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, Inflammation Source Type: research