A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in < i > C. elegans < /i >

How multicellular organisms respond to and are impacted by severe hypothermic stress is largely unknown. FromC. elegans screens for mutants abnormally responding to cold-warming stimuli, we identify a molecular genetic pathway comprising ISY-1, a conserved uncharacterized protein, and ZIP-10, a bZIP-type transcription factor. ISY-1 gatekeeps the ZIP-10 transcriptional program by regulating the microRNAmir-60. Downstream of ISY-1 andmir-60,zip-10 levels rapidly and specifically increase upon transient cold-warming exposure. Prolongedzip-10 up-regulation induces several protease-encoding genes and promotes stress-induced organismic death, or phenoptosis, ofC. elegans.zip-10 deficiency confers enhanced resistance to prolonged cold-warming stress, more prominently in adults than larvae. We conclude that the ZIP-10 genetic program mediates cold-warming response and may have evolved to promote wild-population kin selection under resource-limiting and thermal stress conditions.
Source: eLife - Category: Biomedical Science Tags: Chromosomes and Gene Expression Source Type: research