Targeted deep sequencing of CD34+ cells from peripheral blood can reproduce bone marrow molecular profile in myelodysplastic syndromes

American Journal of Hematology, EarlyView.
Source: American Journal of Hematology - Category: Hematology Authors: Source Type: research

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ConclusionThe characteristic pattern of LAIPs of myeloid blasts with mutatedNPM1 is common and stable, and allows sensitive and specific detection of AML or MDS with mutatedNPM1 after therapy. © 2018 International Clinical Cytometry Society
Source: Cytometry Part B: Clinical Cytometry - Category: Molecular Biology Authors: Tags: Original Article Source Type: research
Conclusion: In our setting, management of CHDs constitutes an economic burden.
Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
FLT3 mutations have been well studied in AML and the detection of FLT3 gene has become a clinical routine. However, it was not fully analyzed in other hematologic malignancies, such as myelodysplastic syndromes (MDS).
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Source Type: research
Authors: Dudina GA, Donetskova AD, Litvina MM, Mitin AN, Mitina TA, Polyakov SA Abstract We have investigated the frequencies of regulatory T cells and the level of FOXP3 isoforms expression in peripheral blood of patients with myelodysplastic syndromes and found the significant reduction of regulatory T cells at all stages of the disease. At the same time in untreated patients, we observed the shift in the FOXP3 isoforms expression profile towards the full-length molecule possibly due to inflammation. Based on the already known information about the potentially higher functional activity of FOXP3 molecule lacking ...
Source: Advances in Hematology - Category: Hematology Tags: Adv Hematol Source Type: research
Conclusion: Pulmonary fungal infections are resistant to treatments for hematological malignancies. Since the treatment of the underlying disease is extended and these infections often recur and are exacerbated, surgery should be considered when possible. PMID: 30402396 [PubMed]
Source: Korean Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Korean J Thorac Cardiovasc Surg Source Type: research
AbstractShwachman-Diamond syndrome (SDS) is a rare inherited disease mainly caused by mutations in the Shwachman-Bodian-Diamond Syndrome (SBDS) gene. However, it has recently been reported that other genes, including DnaJ heat shock protein family (Hsp40) member C21 (DNAJC21), elongation factor-like 1 (EFL1) and signal recognition particle 54 (SRP54) are also associated with an SDS-like phenotype. Interestingly,SBDS, DNAJC21, EFL1 andSRP54 are involved in ribosome biogenesis: SBDS, through direct interaction with EFL1, promotes the release of the eukaryotic initiation factor 6 (eIF6) during ribosome maturation,DNAJC21 stab...
Source: Molecular Diagnosis and Therapy - Category: Molecular Biology Source Type: research
British Journal of Haematology, EarlyView.
Source: British Journal of Haematology - Category: Hematology Authors: Tags: Correspondence Source Type: research
SummaryThe diagnosis of myelodysplastic syndromes (MDS) is often challenging, time ‐ and resource‐consuming. A thorough analysis of complete blood count (CBC) parameters could, however, help to screen for MDS among other causes of cytopenia. To test this hypothesis, 109 newly‐diagnosed MDS patients and 399 cytopenic patients older than 50 years with confirmed absence of MDS were enrolled in a prospective study. Multiparametric analysis highlighted three CBC parameters that were significantly different between the two cohorts: mean corpuscular volume, absolute neutrophil count and median neutrophil complexity and...
Source: British Journal of Haematology - Category: Hematology Authors: Tags: Research Paper Source Type: research
Abstract Myelodysplastic syndromes (MDS) are a varied set of hematologic neoplasms and a high risk of progression to acute myeloid leukemia (AML). 4-Amino-2-trifluoromethyl-phenyl retinate (ATPR), a novel all-trans retinoic acid (ATRA) derivative, play an important role in various types of cancer cells as a tumor inhibitor. However, little is known concerning its antitumor effect on MDS. The cell viability and the percentage of apoptotic cells were used to measure MTT, Flow Cytometry and Hoechst 33342/PI staining. In addition, real-time quantitative RT-PCR (qRT-PCR) and western blotting were used to analyzed the e...
Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Tags: Int Immunopharmacol Source Type: research
Publication date: Available online 7 November 2018Source: Blood Cells, Molecules, and DiseasesAuthor(s): Jin-jun Hu, Jing Xu, Ting-ting Tian, Juan Xie, Li-fang Fan, Guiyang Zhu, Ting Xia, Xi Chen, Yan-hong Tan, Xiu-hua Chen, Fanggang Ren, Yao-fang Zhang, Hong-wei Wang, Zhi-fang XuAbstractTo study the association between TET2rs2454206, TET2rs12498609 and ASXL1rs3746609 and Myelodysplastic syndromes (MDS), a total of 90 MDS patients and 143 healthy volunteers were included. The clinical data, bone marrow samples of patients and peripheral blood samples of volunteers were obtained. We found TET2rs2454206 G/A genotype, TET2rs1...
Source: Blood Cells, Molecules, and Diseases - Category: Hematology Source Type: research
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