Three new eudesmane sesquiterpenoids and a new dimer from the aerial part of Salvia plebeia R. Br.

Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Lie-Feng Ma, Hong Xu, Ji-Dong Wang, Xiang-Min Tong, Zha-Jun Zhan, You-Min Ying, Jian-Wei Wang, Hui Zhang, Wei-Guang Shan Four new compounds, including three eudesmane sesquiterpenoids (1–3) and a dimeric sesquiterpenoid lactone (4), were isolated from the aerial part of Salvia plebeia R. Br., together with two known eudesmanolides (5–6). Their structures were elucidated by extensive spectroscopic analysis including 1D and 2D NMR, HR-ESI–MS spectra. Antiproliferative activities of isolates against six human myeloid leukemia cell lines were evaluated, salplebeone D (1) and G (4) showed moderate inhibitory activity. In addition, compound 4 was a rare eudesmane sesquiterpenoid dimer obtained from this specie for the first time.

Source: Phytochemistry Letters - April 11, 2018 Category: Chemistry Source Type: research