Anthrone derivatives from the terrestrial actinomycete, Actinomadura sp. BCC47066

Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Nantiya Bunbamrung, Khomsan Supong, Chakapong Intaraudom, Aibrohim Dramae, Patchanee Auncharoen, Pattama Pittayakhajonwut Eight new anthrone derivatives, which are (+)-oxanthromicins E (1), F (4), and G (5), (±)-hemi-oxanthromicin D (2), azanthromicin A (7), adxanthromicin A2 (10), 3-methoxy oxanthromicin (11), and (±)-oxanthromicin G (13), along with eight previously described compounds (6, 8, 9, 12, 14–17) have been isolated from the terrestrial actinomycete, Actinomodura sp. BCC47066. The chemical structures have been determined on the basis of NMR spectroscopic information and chemical degradation. The configurations were assigned based upon CD spectral analyses, compared with the related compounds. Furthermore, the isolated compounds were assessed for biological activity. Compounds 10, 12, and 16 showed anti-Bacillus cereus with IC50 in a range of 1.56 − 12.50 μg/mL, while compounds 10 and 12 exhibited anti-phytopathogenic activity against Colletotrichum capsici and C. gloeosporioides with equal IC50 value of 6.25 μg/mL. All tested compounds possessed low cytotoxicity against both malignant and non-malignant cells. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research