Mp69-18 pregnancy with reduced renal mass and nephron count causes metabolic and renal structural changes

Reduced renal volume (RV) and nephron number may be the result of surgery, or congenital or acquired common urinary tract abnormalities such as reflux nephropathy. While signs of reduced RV may not be notable in children or adults routinely, renovascular stress may exacerbate signs of nephron loss. Pregnancy increases renovascular circulation and creates hydroureteronephrosis. Pregnancy with reduced nephron numbers show the effects of stress on reduced RV. We used the 5/6 nephrectomy pregnant rat to examine these changes.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Pediatrics: Urinary Tract Infection & Vesicoureteral Reflux Source Type: research