Methotrexate restores the function of peripheral blood Treg cells in psoriasis vulgaris via CD73/AMPK/mTOR pathway.

CONCLUSION: We speculate that MTX can restore the immunosuppressive function of Treg cells through upregulating CD73, activating AMPK, and inactivating the mTOR pathway. These findings may partly explain the mechanism by which MTX treats psoriasis. This article is protected by copyright. All rights reserved. PMID: 29572822 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29572822?dopt=Abstract

Source: The British Journal of Dermatology - March 23, 2018 Category: Dermatology Authors: Yan K, Xu W, Huang Y, Zhang Z, Huang Q, Xin KZ, Ma Y, Han L Tags: Br J Dermatol Source Type: research

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