Acylated iridoid diglycosides from the cultivated endangered ornamental tree Gmelina hainanensis

Publication date: June 2018 Source:Phytochemistry Letters, Volume 25 Author(s): Juan Xiong, Xi-Ying Wu, Pei-Pei Wang, Choiwan Lau, Hui Fan, Guang-Lei Ma, Yu Tang, Jia Li, Jin-Feng Hu Two new (1 and 2) and 10 known (3−12) acylated iridoid diglycosides were isolated from the twigs and leaves of the cultivated endangered ornamental plant Gmelina hainanensis. Based on spectroscopic data interpretation and chemical transformation, the new triacyl and the new diacyl iridoid diglycosides were established to be 6-O-α-L-(2″,3″-di-O-acetyl-4″-O-cis-cinnamoyl)rhamnopyranosylcatalpol (1) and 6-O-α-l-(2″,4″-di-O-trans-cinnamoyl)rhamnopyranosylcatalpol (2), respectively. All the isolates were evaluated for their inhibitory effects against the protein tyrosine phosphatase 1 B (PTP1B) enzyme. Graphical abstract

Source: Phytochemistry Letters - March 14, 2018 Category: Chemistry Source Type: research