The impact of biological sex on the response to noise and otoprotective therapies against acoustic injury in mice

ConclusionsThese results indicate that female mice are significantly protected from NIHL in comparison to males and that therapeutics for NIHL may have a different effect in males and females. The data highlight the importance of analyzing NIHL experiments from males and females, separately. Finally, these data also raise the possibility of effectors in the estrogen signaling pathway as novel therapeutics for NIHL.

Source: Biology of Sex Differences - March 12, 2018 Category: Biology Source Type: research