Dissecting complex traits using the Drosophila Synthetic Population Resource.

We describe studies using one such panel, the Drosophila Synthetic Population Resource (DSPR), and the implications for our understanding of the genetic basis of complex traits. In particular, we note that many loci of large effect appear to be multiallelic. If multiallelism is a general rule, analytical approaches designed to identify multiallelic variants should be a priority for both genome-wide association studies (GWASs) and multi-parental panels. PMID: 25175100 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/25175100?dopt=Abstract

Source: Trends in Genetics : TIG - August 27, 2014 Category: Genetics & Stem Cells Authors: Long AD, Macdonald SJ, King EG Tags: Trends Genet Source Type: research

More News: Genetics | Study