Hydrocortisone plus Fludrocortisone for Adults with Septic Shock

This research article reported 90-day all-cause mortality was lower in hydrocortisone plus fludrocortisone vs. placebo group. The rate of serious adverse events did not differ significantly, but hyperglycaemia was more common in steroid group.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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Conclusions. Fluid challenge administration was associated with increased PBR (and presumable EG volume changes) which normalized within the next 60 minutes in surgical patients but remained impeded in septic fluid responders. The fluid responsiveness rate after fast and slow FC was comparable, but fast administration tended to induce higher, though transient, response in blood pressure. PMID: 30519590 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
ConclusionsIn patients with sepsis and septic shock, PH is common and is noted to be associated with higher short and long-term mortality. Further studies are needed to understand the mechanisms by which PH is associated with outcomes.
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research
CONCLUSIONS: The significantly elevated urine catecholamine concentrations in EV-A71-stage-4 patients support the hypothesis that hypercatecholaminemia-related heart failure is involved in severe EV-A71 infection. Urine catecholamines could be used as reliable biomarkers for differentiation of severe EV-A71 infection with or without heart failure and septic shock. PMID: 30521401 [PubMed - as supplied by publisher]
Source: Biomarkers - Category: Research Tags: Biomarkers Source Type: research
Septic shock is a leading cause of death in critical patients. In patients with gram-negative septic shock, hemoperfusion with polymyxin B aims to remove endotoxins from plasma. We analyzed the clinical and bi...
Source: Annals of Intensive Care - Category: Intensive Care Authors: Tags: Research Source Type: research
This report utilizes a portion of the data collected in a prospective study, with the aim to identify reliable biomarkers for an early sepsis diagnosis. In the period November 2011 –December 2016, we enrolled 268 patients, admitted to our High-Dependency Unit with a diagnosis severe sepsis/septic shock. Study-related blood samplings were performed at ED-HDU admission (T0), after 6 h (T6) and 24 h (T24): D-dimer, thrombin–antithrombin complex (TAT) and prothrombin fragmen t F1 + 2 levels were analyzed. The primary end-points were day-7 and in-hospital mortality. Day-7 mortality rate was 1...
Source: Internal and Emergency Medicine - Category: Emergency Medicine Source Type: research
Publication date: Available online 5 December 2018Source: Journal of Critical CareAuthor(s): Lex M. van Loon, Johannes G. van der Hoeven, Joris LemsonAbstractThe administration of β-blockers in patients with sepsis is a trending topic in intensive care medicine since the landmark study by Morelli and colleagues, showing a striking decrease in 28-day mortality compared to standard care. While the available evidence suggests that the use of β-blockers in septic shock is safe, the effects on hemodynamics are controversial. In this paper, we review the effect of β-blockade in septic shock on hemodynamics from an...
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research
Conditions:   Polyneuropathies;   Septic Shock;   Muscle Weakness Interventions:   Device: electrical muscle stimulation;   Procedure: conventional physical therapy Sponsor:   University of Chile Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract Sepsis-induced organ failure is characterized by a massive inflammatory response and oxidative stress. Acute kidney injury (AKI) occurs in approximately half of patients in septic shock, and the mortality associated with sepsis-induced AKI is unacceptably high. Klotho is a protein expressed by renal cells and has anti-senescence properties. Klotho has also been shown to protect the kidneys in ischemia-reperfusion injury and to have antioxidant properties. To analyze the role of Klotho in sepsis-related organ dysfunction and AKI, we used a cecal ligation and puncture (CLP) model of sepsis in heterozygous K...
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
Septic shock has been found to disrupt circadian rhythms. Moreover, timing of onset has been associated with different circadian profiles in experimental studies.
Source: Annals of Intensive Care - Category: Intensive Care Authors: Tags: Research Source Type: research
Conditions:   Septic Shock;   Hyperlactatemia;   Peripheral Perfusion Interventions:   Other: CRT guided resuscitation;   Other: Lactate guided resuscitation Sponsors:   Pontificia Universidad Catolica de Chile;   Comisión Nacional de Investigación Científica y Tecnológica Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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