Hydrocortisone plus Fludrocortisone for Adults with Septic Shock
This research article reported 90-day all-cause mortality was lower in hydrocortisone plus fludrocortisone vs. placebo group. The rate of serious adverse events did not differ significantly, but hyperglycaemia was more common in steroid group.
We present a case of a 35-year old Hispanic woman who initially presented with a chief complaint of bilateral lower extremity swelling due to hypoalbuminemia and new-onset hyperkeratotic skin of the palms and soles.Case Rep Oncol 2018;11:404 –411
CONCLUSIONS: Results of this descriptive study were congruent with the literature surrounding the clinical situations that predispose patients to unavoidable PIs. While the implementation of aggressive PI prevention strategies is essential to reducing PI rates, it is important to recognize that in certain populations, such as the critically ill, exposure to certain risk factors may potentially escalate PI risk beyond the scope of prevention and result in an unavoidable PI. Recognizing these risk factors is significant in the journey to differentiate PIs that result from a lack of preventive care from those that may be prevention immune.
Conclusions In a cohort of severe septic patients, we observed that low blood levels of endocan at ICU admission were predictive of ARDS at 72 h.
Sepsis remains a major public health concern, characterized by marked immune dysfunction. Innate lymphoid cells develop from a common lymphoid precursor, but have a role in orchestrating inflammation during innate response to infection. Here we investigate the pathological contribution of the group 2 innate lymphoid cells (ILC2s) in a murine model of acute septic shock (cecal ligation and puncture). Flow cytometric data revealed that ILC2s increase in number and percentage in the small intestine and in the peritoneal cells, and inversely decline in the liver, at 24 hours following septic insult.
Publication date: August 2018 Source:Journal of Critical Care, Volume 46 Author(s): Steven McGloughlin, Guy A. Richards, Mohd Basri Mat Nor, Shirish Prayag, Tim Baker, Pravin Amin Sepsis and septic shock in the tropics are caused by a wide array of organisms. These infections are encountered mainly in low and middle-income countries (LMIC) where a lack of infrastructure and medical facilities contribute to the high morbidity and mortality. Published sepsis guidelines are based on studies primarily performed in high income countries and as such recommendations may or may not be relevant to practice in the tropics. Failure ...
PMID: 29913494 [PubMed - in process]
PMID: 29913493 [PubMed - in process]
Endocan is a circulating proteoglycan measured at high blood levels during severe sepsis, with a likely lung anti-inflammatory function. The aim of this study was to assess whether paradoxically low endocan levels at Intensive Care Unit (ICU) admission could predict Acute Respiratory Distress Syndrome (ARDS) within 72 h in severe septic patients.
To evaluated the outcome predictability of DIC scores in critically ill children with septic shock.