Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8+ T Cells

How glucose metabolism enables rapid acquisition of effector function in memory CD8+ T  cells remains poorly understood. Bantug et al. demonstrate that mitochondria-endoplasmic reticulum contact sites are signaling hubs that enable the metabolic reprogramming required for rapid CD8+ T cell recall responses.

Source: Immunity - March 6, 2018 Category: Allergy & Immunology Authors: Glenn R. Bantug, Marco Fischer, Jasmin Gr ählert, Maria L. Balmer, Gunhild Unterstab, Leyla Develioglu, Rebekah Steiner, Lianjun Zhang, Ana S.H. Costa, Patrick M. Gubser, Anne-Valérie Burgener, Ursula Sauder, Jordan Löliger, Réka Belle, Sarah Dimeloe, Tags: Article Source Type: research