Consumer Information on: XPS System with STEEN Solution Perfusate - H120003

The XVIVO Perfusion System (XPS) with STEEN Solution Perfusate preserves donated lungs that do not initially meet the standard criteria for lung transplantation but may be transplantable if there is more time to observe and evaluate the organ?s function.
Source: Food and Drug Adminstration (FDA): CDRHNew - Category: Medical Equipment Source Type: news

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Heart transplantation is the definitive treatment for end-stage heart failure. A shortage of donor hearts forced transplant programs to accept older donors and longer ischemic times. Previous studies have suggested that the administration of mesenchymal stem cells (MSCs) or their conditioned medium (CM) protects the heart against ischemia/reperfusion injury (IRI). We hypothesized that the preservation of donor hearts with a CM would protect the graft from IRI after prolonged storage in 15-month-old rats and investigated mRNA-changes attributable to CM.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Pre-Clinical Science Source Type: research
Ex vivo lung perfusion (EVLP) is used by an increasing number of transplant centres. It is still controversial whether an acellular or cellular (erythrocyte enriched) perfusate is preferable. The aim of this p...
Source: Respiratory Research - Category: Respiratory Medicine Authors: Tags: Research Source Type: research
uri Francesco Blasi Ex vivo lung perfusion (EVLP) is an emerging procedure that allows organ preservation, assessment and reconditioning, increasing the number of marginal donor lungs for transplantation. However, physiological and airflow measurements are unable to unveil the molecular mechanisms responsible of EVLP beneficial effects on lung graft and monitor the proper course of the treatment. Thus, it is urgent to find specific biomarkers that possess these requirements but also accurate and reliable techniques that identify them. The purpose of this study is to give an overview on the potentiality of shotgun pro...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Purpose of review Recent progress in genetic engineering has facilitated development of transgenic donor animals designed to overcome the known barriers to discordant xenotransplantation, and greatly accelerated progress in the field of xenotransplantation. Here we review and summarize recent progress in lung xenotransplantation, and discuss possible additional genetic modifications and other interventions that may further advance the use of pulmonary xenografts towards clinical applications based on known mechanisms of xeno lung injury. Recent findings Ex-vivo lung perfusion experiments have shown that the addition o...
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: XENOTRANSPLANTATION: Edited by Andrew Adams Source Type: research
Ventricular assist devices (VADs) are currently standard therapy for patients with advanced heart failure that is refractory to medical therapy.1 VADs can be categorized as pulsatile flow VADs (PF-VADs) and continuous flow VADs (CF-VADs). Both PF-VADs and CF-VADs are similarly effective in providing hemodynamic benefit (augmenting cardiac output and end-organ perfusion, and reducing ventricular work), and improving the quality of life and functional capacity of patients.2,3 CF-VADs are preferred over the PF-VADs due to advantages including compact size, reliability, energy efficiency, ease of implantation, and operation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Pre-Clinical Science Source Type: research
ács A, Czebe K, Csiszér E, Mihály S, Kovács L, Müller V, Elek J, Rényi-Vámos F, Lang G Abstract The first lung transplantation in Hungary was performed on 12th of December, 2015. It was a joint effort of the National Institute of Oncology and the Semmelweis University. Hereby we summarise the results and experiences from the first three years. Until August, 2018, 55 lung transplantations were performed in Hungary. This was a retrospective analysis. All patients were listed according to the recommendation of the Lung Transplantation Committee. All implanted lungs have ...
Source: Orvosi Hetilap - Category: General Medicine Authors: Tags: Orv Hetil Source Type: research
AbstractPurpose of ReviewPrimary graft dysfunction is an acute lung injury syndrome occurring immediately following lung transplantation. This review aims to provide an overview of the current understanding of primary graft dysfunction (PGD), including epidemiology, immunology, clinical outcomes, and management.Recent FindingsIdentification of donor and recipient factors allowing accurate prediction of PGD has been actively pursued. Improved understanding of the immunology underlying PGD has spurred interest in identifying relevant biomarkers. Work in PGD prediction, severity stratification, and targeted therapies continue...
Source: Current Respiratory Care Reports - Category: Respiratory Medicine Source Type: research
American Journal of Transplantation, EarlyView.
Source: American Journal of Transplantation - Category: Transplant Surgery Authors: Source Type: research
Aortic valve incompetence in left ventricular assist device (LVAD) patients is a significant management problem, leading to increased workload on the LVAD and inadequate systemic perfusion. During continuous LVAD therapy even mild aortic incompetence is problematic, associated with reduced aortic leaflet opening, progressive fusion of the leaflets and worsening valvular incompetence. Therefore, repair or replacement of the valve is required at the time of LVAD implant.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Case Anecdotes, Comments and Opinions Source Type: research
Normothermic ex-vivo lung perfusion (EVLP) is a new emerging technique to select lungs from extended-criteria donors. These lungs present edema due to brain-death, harvesting, preservation, or ischemia-reperfusion. However, the identification of appropriate organs is crucial. Combined bench techniques during EVLP rehabilitation are proposed to better assess lung function and predict an adequate graft [1 –3]. However, accurate assessment of the lungs remains challenging because the common tools are insufficiently correlated to the occurrence and severity of primary graft dysfunction (PGD) in recipients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
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