GSE99418 Pairwise and higher order genetic interactions in the evolution of a tRNA

Contributors : J úlia Domingo ; Guillaume Diss ; Ben LehnerSeries Type : Genome variation profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeA central question in genetics and evolution is the extent to which mutations have outcomes that change depending on the genetic context in which they occur. Pairwise interactions between mutations have been systematically mapped within and between genes, and contribute substantially to phenotypic variation amongst individuals. However, the extent to which these epistatic interactions themselves are stable or dynamic across genotypes is unclear. Here we quantify 44,497 genetic interactions between the same pairs of mutations across>400 closely-related genotypes of a yeast tRNA. Strikingly, all pairs of mutations interacted in at least 28% of genetic backgrounds (FDR

Source: GEO: Gene Expression Omnibus - March 6, 2018 Category: Genetics & Stem Cells Tags: Genome variation profiling by high throughput sequencing Saccharomyces cerevisiae Source Type: research