What is penis cancer? Five signs of rare disease that should be seen by a GP now

CANCER symptoms vary depending on where the tumour is on the body. But, you should see a GP if you have these signs and symptoms of the rare penis cancer.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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CONCLUSION: The incidence of penile cancer in Saxony has increased in recent years, while mortality has decreased. However, survival rates have remained constant over time. PMID: 30595462 [PubMed - as supplied by publisher]
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Tags: Urol Oncol Source Type: research
CONCLUSION: The node positivity rate in patients with T1 to T4 and N0 is 9%, much lower than reported in penile cancer with a high-risk primary tumor but clinically negative groins. This argues against routine prophylactic inguinal ILND in patients with urethral SCC who are clinically N0, perhaps suggesting different biological behavior of urethral SCC compared to penile SCC. Performing a lymph node dissection in patients with clinically N1 or N2 disease is associated with improved OS. PMID: 30446445 [PubMed - as supplied by publisher]
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Tags: Urol Oncol Source Type: research
CONCLUSION: Penile cancer is curable in all early stages with the appropriate treatment, but its prognosis depends crucially on the proper management of the regional (i.e., inguinal) lymph nodes. In many countries, the treatment of this rare disease entity has been centralized. PMID: 30375327 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
Human penile cancer is a rare disease in developed countries with an incidence rate of around 1 per 100,000 [1]. In contrast, it is more common in developing countries accounting for up to 10% to 17% of cancer in males with an incidence that reaches 4 per 100,000 [1,2]. Squamous cell carcinoma (SCC) is the predominant cancer type and accounts for over 95% of penile cancer cases [3 –5]. The main treatment for advanced tumors is phalectomy and, when inguinal lymph node metastasis is present, bilateral inguinal lymphadenectomy is also performed.
Source: Urologic Oncology: Seminars and Original Investigations - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
Authors: Marchioni M, Berardinelli F, De Nunzio C, Spiess P, Porpiglia F, Schips L, Cindolo L Abstract Penile cancer is a rare disease. Most of penile cancer are squamous cell carcinoma. Diagnosis is based on self-examination, clinical examination and confirmatory biopsy. Several imaging technique could be used for staging purpose. However, the best modality for staging in intermediate and high risk patients is by surgical evaluation and the use of inguinal lymph node dissection, that has also a therapeutic effect. Unfortunately, inguinal lymph node dissection is underused. Penile cancer treatment may have a major ...
Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
Publication date: August 2018Source: European Urology Supplements, Volume 17, Issue 6Author(s): Andrea NecchiAbstractPenile squamous cell carcinoma (PSCC) is a very rare disease and its prognosis primarily depends on regional lymph node involvement. Although a cure can be obtained in patients with a low metastatic burden using surgery as standalone option, combined modality therapy is required for more advanced cases. In patients with multiple fixed or bulky inguinal lymph nodes, and in those with enlarged pelvic lymph nodes, chemotherapy is moderately effective, with an objective response rate of approximately 50% if a tr...
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Authors: Takamoto D, Kawahara T, Kasuga J, Sasaki T, Yao M, Yumura Y, Uemura H Abstract Primary penile cancer is a rare disease. Higher incidence rates occur in underdeveloped countries. Many studies have suggested an association between human papillomavirus (HPV) infection and penile cancer. Although HPV can affect the squamous epithelium of the male genitalia similarly to the female genital tract, the association between penile cancer and HPV remains unclear. In the present study, the HPV gene expression was examined in penile cancer tissue using in situ hybridization (ISH). The present study included 41 cases in...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Urethral squamous cell carcinoma (SCC) is a rare disease with limited clinical recommendations. Despite the similarities to penile cancer in terms of histology and lymphatic drainage, no consensus exists on the role of inguinal lymph node dissection (LND) for men with high-risk tumors. We sought to define the rate of inguinal LND performance and its implication on survival.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Sexual Function/Dysfunction: Penis/Testis/Urethra: Benign Disease & Malignant Disease I Source Type: research
Abstract OBJECTIVES: To evaluate whether socioeconomic factors affect pathologic stage, treatment delays, pathologic upstaging, and overall survival (OS) in patients with penile cancer (PC). PATIENTS AND METHODS: A total of 13,283 eligible patients diagnosed with PC from 1998 to 2012 were identified from the National Cancer Database. Socioeconomic, demographic and pathologic variables were used in multivariable regression models to identify predictors of pathologic T stage ≥2, pathologic lymph node positivity, cT to pT upstaging, treatment delays, and OS. RESULTS: A 5-year OS was 61.5% with a median f...
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Tags: Urol Oncol Source Type: research
Publication date: Available online 6 September 2017 Source:European Urology Supplements Author(s): Andrea Necchi Penile squamous cell carcinoma (PSCC) is a very rare disease and its prognosis primarily depends on regional lymph node involvement. Although a cure can be obtained in patients with a low metastatic burden using surgery as standalone option, combined modality therapy is required for more advanced cases. In patients with multiple fixed or bulky inguinal lymph nodes, and in those with enlarged pelvic lymph nodes, chemotherapy is moderately effective, with an objective response rate of approximately 50% if a tripl...
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
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