Synthesis, crystal structure, and antinociceptive effects of some new riluzole derivatives

This study investigated the antinociceptive activity of some N-alkylated derivatives of riluzole by hot plate test in mice. The relationship between antinociceptive activity and the doses of4b,4c,4h,4g, and riluzole had been studied. Compared with the control group (0  mg/kg), the effects of compounds4b and4h showed a significant increase (13.78  ± 2.89 s, 12.89 ± 2.94 s, respectively). Compound4c showed extreme significant increase (18.07  ± 3.08 s) in the time mice spent on the hot plate. The compounds4b,4c, and4h had increased the latency time compared to the blank solvent group. They have potential application in developing new drug candidates with antinociceptive activity.

Source: Medicinal Chemistry Research - March 2, 2018 Category: Chemistry Source Type: research