Facile synthesis of pyrazoles by iron-catalyzed regioselective cyclization of hydrazone and 1,2-diol under ligand-free conditions

Publication date: Available online 26 February 2018 Source:Journal of Organometallic Chemistry Author(s): Niranjan Panda, Subhadra Ojha A facile synthesis of pyrazoles by the cyclization of hydrazones and 1,2-diols was described. In the presence of ferric nitrate, the reaction occurs under neat conditions and makes the use of potassium persulfate to oxidize the diol to α-hydroxy carbaldehyde for the reaction with hydrazones to produce 1,3- and 1,3,5-substituted pyrazoles selectively. The overall regioselective transformation occurs in one-pot under ligand-free, mild conditions even in the presence of air. Graphical abstract

Source: Journal of Organometallic Chemistry - February 27, 2018 Category: Chemistry Source Type: research