Deficiency in the DNA glycosylases UNG1 and OGG1 does not potentiate c-myc-induced B-cell lymphomagenesis

C-Myc overexpression mediates lymphomagenesis, however, secondary genetic lesions are required for its full oncogenic potential. The origin and the mechanism of formation of these mutations are unclear. Using the lacI-mutation detection system, we show that secondary mutations occur early in B-cell development and are repaired by Msh2. The mutations at the lacI gene were predominantly at C:G base pairs and CpG motifs suggesting that they were formed due to cytosine deamination or oxidative damage of G.

Source: Experimental Hematology - February 26, 2018 Category: Hematology Authors: Blerta Green, Alberto Martin, Antoaneta Belcheva Source Type: research