Synthesis, theoretical, and experimental study of radical scavenging activity of 3-pyridinol containing trans -resveratrol analogs

AbstractIn the search of more powerful and versatile antioxidant agents for biomedical applications, a structural modification of the resveratrol scaffold was carried out. Sixtrans-resveratrol (TR) analogs with atrans-stilbazole framework were obtained. Quantum calculations based on the density functional theory (DFT) were used to study the relationship between the structure of synthesized compounds and antioxidant activity. Calculations have shown that derivatives2b,2c, and2e should exhibit higher antioxidant activity than TR, whereas2a,2d, and3a are less effective antioxidants. The obtained data correlate well with the results of the analysis carried out with diphenyl-1-picrylhydrazyl (DPPH). All compounds showed a lower cytotoxicity compared to TR in the MTT test on mouse fibroblast cells L929.
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research