The cohort multiple randomized controlled trial design was found to be highly susceptible to low statistical power and internal validity biases
The “cohort multiple randomized controlled trial” (cmRCT) is a recent innovation by which novel interventions are trialed within large longitudinal cohorts of patients to gain efficiencies and align trials more closely to standard clinical practice. The use of cmRCTs is outpacing its methodological understanding, and more appropriate methods for designing and analyzing such trials are urgently needed.
Source: Journal of Clinical Epidemiology - Category: Epidemiology Authors: David Reeves, Kelly Howells, Mark Sidaway, Amy Blakemore, Mark Hann, Maria Panagioti, Peter Bower Tags: Original Article Source Type: research
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