T cell receptors for the HIV KK10 epitope from patients with differential immunologic control are functionally indistinguishable [Immunology and Inflammation]

HIV controllers (HCs) are individuals who can naturally control HIV infection, partially due to potent HIV-specific CD8+ T cell responses. Here, we examined the hypothesis that superior function of CD8+ T cells from HCs is encoded by their T cell receptors (TCRs). We compared the functional properties of immunodominant HIV-specific...

Source: Proceedings of the National Academy of Sciences - February 20, 2018 Category: Science Authors: Alok V. Joglekar, Zhe Liu, Jeffrey K. Weber, Yong Ouyang, John D. Jeppson, Won Jun Noh, Pedro A. Lamothe-Molina, Huabiao Chen, Seung-gu Kang, Michael T. Bethune, Ruhong Zhou, Bruce D. Walker, David Baltimore Tags: Biological Sciences Source Type: research