Mechanism of ubiquitin transfer promoted by TRAF6 [Biochemistry]

Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) plays a vital role in immune signal transduction pathways by acting as a ubiquitin ligase (E3) for Lys63-linked polyubiquitin chain synthesis. However, the detailed mechanism by which the TRAF6 RING dimer promotes ubiquitin transfer was unknown. Through structural modeling and biochemical analysis,...

Source: Proceedings of the National Academy of Sciences - February 20, 2018 Category: Science Authors: Tian-Min Fu, Chen Shen, Qiubai Li, Pengfei Zhang, Hao Wu Tags: Biological Sciences Source Type: research