Zimbabwe:Scrap Cancer Therapy Charges - First Lady
[The Herald] First Lady Auxillia Mnangagwa has appealed to Government to scrap radiotherapy charges for cancer patients. Addressing hundreds of people in Masvingo, she said the current $400 charge per session was beyond the reach of many cancer patients.
Cutaneous adverse drug reactions (ADRs) occur in nearly all patients undergoing anti-cancer therapy, contributing to morbidity, therapy disruptions, and rising health care costs. ADR characterization is hampered by clinical trials underpowered to detect rare events, division of patients across institutions, patient exclusion from trials, publication editorial delays, and infrequent dermatologist participation in oncologic care. Early ADR recognition could substantially improve health outcomes and decrease societal costs.
Cancer therapies commonly slow disease and most patients ultimately relapse. Here we show at the single-cell level that cutaneous lymphoma cells are programmed to occupy a rare transient, drug-resistant state. Our work defines a panel of drug-resistance markers allowing identification of this cellular subset in patients. Single-cell analyses reveal a small fraction of cells resisting commonly used drugs such as doxorubicin, vorinostat, and methotrexate. In cell fate analyses, we observed that drug treatment leads to selective survival of label-retaining cells leading to re-growth of xenograft tumors consistent with a relap...
Polymeric micelle is consisted of poly (ethylene glycol) - poly (amino acid) block copolymer formed micelles through the self-assembly of block copolymers. This micelle has been recognized as a systemic nanocarrier in targeted cancer therapy. It is known as the nanoparticle formation for mainly hydrophobic drug encapsulated in the micelles, and has characteristics of increased drug solubility, its sustainable release and tissue distribution. The polymeric micelle shows high stability characterized by low micelle concentration as compared with general surfactants.
The majority of cancer deaths are associated with metastasis, the process of cancer cells spreading from primary tumor sites and forming new tumors at distant organs. Circulating tumor cells (CTCs) are the key determinants of metastatic propensity. Detection and characterization of CTCs is critical for understanding tumor metastasis and improving cancer therapy. Here, we applied a linear-array-based photoacoustic tomography (LA-PAT) system for label-free high-throughput melanoma CTC imaging in patients in vivo.
Little is known about the impact of melanoma stage and treatment on quality of life (QoL).The Functional Assessment of Cancer Therapy Melanoma (FACT-M) was completed by 87 patients at an academic institution in 2015-2016. Scores were compared between localized and advanced-stage patients. FACT-M scores were converted to European Quality of Life-5 Dimensions (EQ-5D) scores for derivation of health utilities. Melanoma was associated with reduced utility compared to the general population (0.76 vs 0.87, respectively).
In conclusion, our data show that Notch signaling affects the hypoxic response via regulation of HIF2a, which may be important for future cancer therapies.
arner A growing body of evidence suggests that a subset of cells within tumors are resistant to conventional treatment modalities and may be responsible for disease recurrence. These cells are called cancer stem cells (CSC), which share properties with normal stem cells including self-renewal, pluripotency, drug resistance, and the ability to maintain quiescence. While most conventional therapies can efficiently destroy rapidly dividing cancer cells comprising the bulk of a tumor, they often fail to kill the less abundant and quiescent CSCs. Furthermore, killing of only differentiated cells in the tumor may actually al...
ConclusionThe developed framework provides a thorough description of FACT-B longitudinal data. It acknowledges the multi-dimensional nature of the questionnaire and allows covariate and exposure effects to be evaluated on responses.
Chloroquine inhibits cell growth in human A549 lung cancer cells by blocking autophagy and inducing mitochondrial‑mediated apoptosis. Oncol Rep. 2018 Apr 12;: Authors: Liu L, Han C, Yu H, Zhu W, Cui H, Zheng L, Zhang C, Yue L Abstract Chloroquine (CQ) has been revealed to exhibit antitumor activity in several human tumors including lung cancer as mono‑ or add‑on therapy. The antitumor effect of CQ appears to depend on the tumor type, stage and genetic context. Few studies have focused on the mechanism concerning the antitumor effect of CQ monotherapy and the cause and effect relationship amo...
I'm interested in pursuing Radiation Oncology, and was hoping to hear some thoughts on what the future will be like for Radiation Oncologists with some of the advancements in cancer therapy coming out (immunotherapy, for example). From my naive perspective, it seems like the future is pretty uncertain.