Glycogen synthase kinase 3 β promotes liver innate immune activation by restraining AMP-activated protein kinase activation

Liver inflammation triggered by ischemia reperfusion (IR) is an innate immune-dominated response, mediated by the sentinel pattern recognition receptor (PRR) system [1,2]. Danger associated molecular patterns (DAMPs) [3], such as HMGB-1, released from necrotic/stressed cells [4 –6], activates PRRs including TLRs and NLRs [7–10] to initiate the pro-inflammatory immune response. At the cellular level, macrophages, the predominant innate immune cells in livers, play a major role in reacting to DAMPs to trigger tissue inflammatory immune response.

Source: Journal of Hepatology - February 13, 2018 Category: Gastroenterology Authors: Haoming Zhou, Han Wang, Ming Ni, Shi Yue, Yongxiang Xia, Ronald W. Busuttil, Jerzy W. Kupiec-Weglinski, Ling Lu, Xuehao Wang, Yuan Zhai Source Type: research