Cognitive impairment and risk of future stroke: a systematic review and meta-analysis.

Cognitive impairment and risk of future stroke: a systematic review and meta-analysis. CMAJ. 2014 Aug 25; Authors: Lee M, Saver JL, Hong KS, Wu YL, Liu HC, Rao NM, Ovbiagele B Abstract BACKGROUND: Several studies have assessed the link between cognitive impairment and risk of future stroke, but results have been inconsistent. We conducted a systematic review and meta-analysis of cohort studies to determine the association between cognitive impairment and risk of future stroke. METHODS: We searched MEDLINE and Embase (1966 to November 2013) and conducted a manual search of bibliographies of relevant retrieved articles and reviews. We included cohort studies that reported multivariable adjusted relative risks and 95% confidence intervals or standard errors for stroke with respect to baseline cognitive impairment. RESULTS: We identified 18 cohort studies (total 121 879 participants) and 7799 stroke events. Pooled analysis of results from all studies showed that stroke risk increased among patients with cognitive impairment at baseline (relative risk [RR] 1.39, 95% confidence interval [CI] 1.24-1.56). The results were similar when we restricted the analysis to studies that used a widely adopted definition of cognitive impairment (i.e., Mini-Mental State Examination score < 25 or nearest equivalent) (RR 1.64, 95% CI 1.46-1.84). Cognitive impairment at baseline was also associated with an increased risk of fatal stroke (...
Source: cmaj - Category: Journals (General) Authors: Tags: CMAJ Source Type: research