Increased alcohol seeking in mice lacking Gpr88 involves dysfunctional mesocorticolimbic networks

Alcohol Use Disorders (AUDs) are devastating and poorly treated, and innovative targets are actively sought for prevention and treatment. The orphan G protein-coupled receptor GPR88 is enriched in mesocorticolimbic pathways, and Gpr88 knockout mice show hyperactivity and risk-taking behavior, but a potential role for this receptor in drug abuse has not been examined.

Source: Biological Psychiatry - February 9, 2018 Category: Psychiatry Authors: Sami Ben Hamida, Sueli Netto, Tanzil Mahmud Arefin, Md. Taufiq Nasseef, Laura-Joy Boulos, Michael McNicholas, Aliza Toby Ehrlich, Eleanor Clarke, Luc Moquin, Alain Gratton, Emmanuel Darcq, Harsan Laura Adela, Rafael Maldonado, Brigitte Lina Kieffer Tags: Archival Report Source Type: research