Corrigendum: Enhanced Cytotoxic Effects of Combined Valproic Acid and the Aurora Kinase Inhibitor VE465 on Gynecologic Cancer Cells

Yanfang Li, Tao Liu, Cristina Ivan, Jie Huang, De-Yu Shen, John J. Kavanagh, Robert C. Bast, Siqing Fu, Wei Hu, Anil K. Sood
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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Authors: Carroll K, Mesman J, McLeod H, Boughey J, Keeney G, Habermann E Abstract Utilising frozen section technologies, Mayo Clinic has one of the lowest reoperation rates for breast lumpectomy in the United States. The research reported on sought to understand the successful teamwork between the Breast Surgery Team and the Frozen Section Laboratory at Mayo Clinic. Researchers worked collaboratively with healthcare staff from breast surgery and the frozen section pathology laboratory to identify communication styles and strategies that contribute to the timely and accurate intraoperative evaluation of breast cance...
Source: Journal of Interprofessional Care - Category: Health Management Tags: J Interprof Care Source Type: research
ConclusionsNIV showed a significant protective effect for intubation in immunosuppressed patients (cancer and transplants) and in patients with APE/CAP. However, the benefits of NIV for other etiologies are not clear and more trials are needed to prove these effects.
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research
A new study shows a drug targeting the immune system could help women with an aggressive type of breast cancer. The results were announced at a conference in Europe and could change the way women are treated. Dr. Jon LaPook reports.
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
Publication date: Available online 19 October 2018Source: Pharmacology &TherapeuticsAuthor(s): Ryuji Yamaguchi, Lydia Lartigue, Guy PerkinsAbstractRegulation of both the extrinsic and the mitochondria-dependent intrinsic apoptotic pathways plays a key role in the development of the hematopoietic system, for sustaining cell survival during generation of various cell types, in eliminating cells with dual identities such as CD4/CD8 double-positive cells1,2, for sustaining cells during the rapid clonal expansion phase3, as well as eliminating cells during the contraction phase4. The anti-apoptotic protein Mcl-1 is necessar...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 19 October 2018Source: Pharmacology &TherapeuticsAuthor(s): Joseph T. Madak, Armand Bankhead, Christine R. Cuthbertson, Hollis D. Showalter, Nouri NeamatiAbstractIdentified as a hallmark of cancer, metabolic reprogramming allows cancer cells to rapidly proliferate, resist chemotherapies, invade, metastasize, and survive a nutrient-deprived microenvironment. Rapidly growing cells depend on sufficient concentrations of nucleotides to sustain proliferation. One enzyme essential for the de novo biosynthesis of pyrimidine-based nucleotides is dihydroorotate dehydrogenase (DHODH), a known t...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 19 October 2018Source: Pharmacology &TherapeuticsAuthor(s): Xiangjin Zheng, Wan Li, Liwen Ren, Jinyi Liu, Xiaocong Pang, Xiuping Chen, De Kang, Jinhua Wang, Guanhua DuAbstractSphingolipid metabolites, such as ceramide, sphingosine and sphingosine-1-phosphate (S1P), play many important roles in cellular activities. Ceramide and sphingosine inhibit cell proliferation and induce cell apoptosis while S1P has the opposite effect. Maintaining a metabolic balance of sphingolipids is essential for growth and development of cells. Sphingosine kinase (SPHK) is an important regulator for keeping...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
This study highlighted the impact of each gum ingredient on the quality of the MCGs and demonstrated the feasibility of preparing chewing gums with up to 50% drug loading.Graphical abstract
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
ConclusionMiR-21 suppressed the Hippo signaling pathway and promoted the progression of LAD through targeting KIBRA.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: December 2018Source: Biomedicine &Pharmacotherapy, Volume 108Author(s): Sri Renukadevi Balusamy, Haribalan Perumalsamy, Md. Amdad Huq, Balamuralikrishnan BalasubramanianAbstractOriganum vulgare commonly known as oregano belongs to mint family (Laminaceae), and native to temperate western and mediterranean region. In our present study, we have identified the bio-active principles of oregano essential oil (EO) and evaluated its apoptotic effects against human stomach cancer cell lines (AGS). The EO altered colony forming characteristics of cancer cell, migration ability of cancer cell and thus prevented...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
ConclusionApplication of cytostatic drugs in combination with apoptogenic plant extracts induced significant changes in transcriptome-wide mRNA microarray profiles of neuroglial cells. These changes indicate on potential beneficial effects on neuronal functions associated with mild cognitive impairments in cancer chemotherapy.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
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