Control of B-1a cell development by instructive BCR signaling.

Control of B-1a cell development by instructive BCR signaling.
Curr Opin Immunol. 2018 Feb 03;51:24-31
Authors: Kreslavsky T, Wong JB, Fischer M, Skok JA, Busslinger M
Abstract
B-1a cells remain one of the most enigmatic lymphocyte subsets. In this review, we discuss recent advances in our understanding of the development of these cells and their regulation by the transcription factors Bhlhe41 and Arid3a as well as by the RNA-binding protein Lin28b. A large body of literature supports an instructive role of BCR signaling in B-1a cell development and lineage commitment, which is initiated only after signaling from an autoreactive BCR. While both fetal and adult hematopoiesis can generate B-1a cells, the contribution of adult hematopoiesis to the B-1a cell compartment is low under physiological conditions. We discuss several models that can reconcile the instructive role of BCR signaling with this fetal bias in B-1a cell development.
PMID: 29414528 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - February 3, 2018 Category: Allergy & Immunology Authors: Kreslavsky T, Wong JB, Fischer M, Skok JA, Busslinger M Tags: Curr Opin Immunol Source Type: research