The'Ugly Duckling' Rule in Melanoma Self-exam The'Ugly Duckling' Rule in Melanoma Self-exam
Compared with the more traditional ABCD rule, does the'ugly duckling'sign improve melanoma detection?Medscape Dermatology
Inflammatory skin diseases cause more harm than skin cancers when years of disability and mortality are added together, according to the latest report from the Global Burden of Disease Study.Medscape Medical News
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Authors: da Silva Junior IA, Stone SC, Rossetti RM, Jancar S, Lepique AP Abstract Platelet-activating factor (PAF) plays an important role in the pathogenesis of several types of tumors. The biological effects of PAF are mediated by the PAF receptor (PAFR), which can be expressed by tumor cells and host cells that infiltrate the tumor microenvironment. In the present study, we investigated the role of PAFR expressed by leukocytes that infiltrate two types of tumors, one that expresses PAFR (TC-1 carcinoma) and another that does not express the receptor (B16F10 melanoma) implanted in mice that express the receptor o...
Contributors : Kevin Bi ; Brian C Miller ; Jeffrey J IshizukaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusKnockout of Adar1 in B16 melanoma results in global reprogramming of the tumor immune microenvironment
Publication date: Available online 16 February 2018 Source:Journal of Pharmacological Sciences Author(s): Jia Hu, Xuedan Guo, Lijia Yang Melanoma is one of the most malignant skin tumors with high mortality rate. Morin has been reported to treat several cancers. However, whether or how Morin affects melanoma progression is still poorly understood. Either Morin treatment or miR-216a overexpression reduced cell viability, sphere formation ability and expressions of stem cell marker genes CD20, CD44, CD133 and Wnt-3A. MiR-216a was induced by Morin treatment in CD133+ melanoma cells. Melanoma xenograft model treated by Morin ...
In conclusion, functional expression of EphB4 is considered a promising differentiating characteristic, preferentially determined by non-invasive in vivo imaging, which may improve personalized theranostics of malignant melanoma.
Cutaneous malignancy of the head and neck affects a large proportion of elderly patients. The severity ranges from small, easily treatable lesions to large, invasive, potentially metastatic tumors. Surgical treatment is the primary treatment of most skin cancers; however, geriatric patients are more likely to have multiple comorbidities that increase the risk of surgery. Multiple treatment modalities exist, including surgical, radiation, and medical therapy. Recommendations and treatment options for basal cell carcinoma, squamous cell carcinoma, Merkel cell carcinoma, and melanoma are outlined and reviewed.
This article is protected by copyright. All rights reserved. PMID: 29453787 [PubMed - as supplied by publisher]