Recent Reports About HIFU'Troubling'Recent Reports About HIFU'Troubling '

Despite new reports of HIFU for focalized therapy of prostate cancer, Dr Chodak remains unconvinced of its evidence.Medscape Urology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Urology Commentary Source Type: news

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MR imaging-guided focal therapy is a viable treatment option for patients with localized prostate cancer. After the identification of a malignant focus in the prostate gland on multiparametric MR imaging, treatment can be directed in a precise fashion to the area of interest. The goal of focal therapy is to eradicate prostate cancer while minimizing complications that can affect quality of life. Currently, the most commonly used methods of focal treatment of prostate cancer are cryotherapy, high-intensity focused ultrasound, and laser ablation.
Source: Magnetic Resonance Imaging Clinics of North America - Category: Radiology Authors: Source Type: research
ConclusionThis work demonstrates the feasibility of utilizing a planar CMUT probe for generating dynamic HIFU focusing and lesioning compatible with the ablation of prostate tissues under endocavitary treatment approach. Future investigations will consist of validating the lesioning capability experimentally both in vitro and in vivo.Graphical abstract
Source: IRBM - Category: Biomedical Engineering Source Type: research
Publication date: November 2018Source: European Journal of Surgical Oncology, Volume 44, Issue 11Author(s): Daniel Ball, Na Hyun Kim, Ashley McFarlane, Taimur Shah, Max Peters, Enrique Gomez, Saiful Miah, Stephanie Guillaumier, Naveed Afzai, Tim Dudderidge, Feargus Hosking-Jervis, David Eldred-Evans, Richard Hindley, Henry Lewl, Neil McCartan, Caroline Moors, Manit Arya, Raj Nigam, Chris Ogden, Raj Persad
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Purpose of review With the increasing incidence of low-to-intermediate risk of prostate cancer (PCa) by the introduction of prostate-specific antigen (PSA) screening, focal therapy has become one of the promising treatment options in the world. In Asia, same movement are occurring using several technologies including cryoablation, high-intensity focused ultrasound, brachytherapy and irreversible electroporation. However, these are still not common strategies to treat organ-confined PCa. The purpose of this review is to summarize the most updated experience and future direction of focal therapy in Asian countries. Recent...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: FOCAL THERAPY OF PROSTATE AND KIDNEY CANCER: Edited by Jean de la Rosette and Thomas J. Polascik Source Type: research
Purpose of review The aim of this study was to summarize the latest evidence, as well as the rationale behind using focal therapy for the treatment of prostate cancer. With patients becoming more educated, knowledge of the available evidence is key when discussing treatment. Recent findings In older works, the natural history of prostate cancer has been described as being multifocal, driven by one index lesion. This represents the key argument for most experts, why focal therapy is feasible in prostate cancer. Most modalities have similar results. For high-intensity focussed ultrasound (HIFU), a pooled data analysis w...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: FOCAL THERAPY OF PROSTATE AND KIDNEY CANCER: Edited by Jean de la Rosette and Thomas J. Polascik Source Type: research
Authors: Arnouil N, Gelet A, Matillon X, Rouviere O, Colombel M, Ruffion A, Mège-Lechevallier F, Subtil F, Badet L, Crouzet S Abstract OBJECTIVE: To analyse the functional and oncologic outcomes at one year of focal therapy with HIFU compared with total prostatectomy in patients with localised prostate cancer (PCa). PATIENTS AND METHODS: Retrospective and monocentric study from 2008 to 2014 comparing 2 cohorts of patients with localised PCa (T1/T2 clinical stage, Gleason score≤3+4=7 and PSA
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
Immunohistochemical and morphometric analysis of the microcirculatory bed in the tumor and non-tumor parenchyma of the prostate was carried out with the use of endothelial cell marker CD34 in patients treated by high-intensity focused ultrasound (HIFU). The numerical density of microvessels in the adenocarcinoma focus did not correlate with the degree of its differentiation, while high values of this parameter were associated with lower incidence of local progression after HIFU. Effective HIFU ablation led to progressive fibrosis and significant reduction of the microcirculatory bed in zones of intact non-tumor glands in c...
Source: Bulletin of Experimental Biology and Medicine - Category: Biology Source Type: research
ConclusionMRgFUS is a feasible and safe method of noninvasively ablating low –intermediate risk PCa with acceptable short-term oncologic outcomes.Key Points•Focal therapy selectively ablates locally confined, clinically significant index lesion with a margin while sparing rest of gland and adjacent vital structures.•Magnetic resonance-guided focused high frequency ultrasound surgery (MRgFUS) combines MRI with HIFU.•MRgFUS provides ability to monitor treatments in real time and allows a targeted approach for focal ablation.•MRgFUS is a feasible, safe method of noninvasively ablating low –inte...
Source: European Radiology - Category: Radiology Source Type: research
PMID: 30178293 [PubMed - as supplied by publisher]
Source: Der Urologe. Ausg. A - Category: Urology & Nephrology Authors: Tags: Urologe A Source Type: research
Immunohistochemical and morphometric analysis of the microcirculatory bed in the tumor and non-tumor parenchyma of the prostate was carried out with the use of endothelial cell marker CD34 in patients treated by high-intensity focused ultrasound (HIFU). The numerical density of microvessels in the adenocarcinoma focus did not correlate with the degree of its differentiation, while high values of this parameter were associated with lower incidence of local progression after HIFU. Effective HIFU ablation led to progressive fibrosis and significant reduction of the microcirculatory bed in zones of intact non-tumor glands in c...
Source: Bulletin of Experimental Biology and Medicine - Category: Biology Source Type: research
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