Recent Reports About HIFU'Troubling'Recent Reports About HIFU'Troubling '
Despite new reports of HIFU for focalized therapy of prostate cancer, Dr Chodak remains unconvinced of its evidence.Medscape Urology
Authors: Linares-Espinós E, Carneiro A, Martínez-Salamanca JI, Bianco F, Castro-Alfaro A, Cathelineau X, Valerio M, Sanchez-Salas R Abstract BACKGROUND: The aim of this study was to review the oncological and functional outcomes of new and established primary focal treatments (FT) for localized prostate cancer (PCa). METHODS: We performed a systematic search of published studies on FT for localized PCa using electronic databases (Medline and Embase). These studies included reports on hemiablation, focal ablation and target-ablation. We excluded salvage focal therapy studies and limited the search ...
ABSTRACT Background Some men with localized radio-recurrent prostate cancer may benefit from salvage high-intensity focused ultrasound (HIFU). Herein, we describe oncologic outcomes and predictors of disease response after salvage whole gland HIFU from our prospective cohort. Materials and Methods Patients with localized radio-recurrent prostate cancer were prospectively enrolled from January 2005 to December 2014. Participants had to meet both biochemical and histological definitions of recurrence. Exclusion criteria included the receipt of prior salvage therapy, presence of metastatic disease, and administration of ADT i...
CONCLUSIONS: CEUS examination showed a reduction of microcirculation in the treated area immediately after the treatment and 24 hours later. The combination of CEUS and image fusion seems to be helpful for detecting the PCa target lesion and monitor the success of HIFU ablation treatment. Evidence for image findings after HIFU-therapy are rare. Further studies on this topic are needed. PMID: 29660918 [PubMed - as supplied by publisher]
Insurance coverage of the relatively new technology for salvage therapy was called'pretty remarkable'by a urologist who uses high-intensity focused ultrasound (HIFU).Medscape Medical News
The objective of our study was to evaluate oncologic and functional outcomes of salvage high-intensity focused ultrasound (S-HIFU) for locally recurrent PCa after LDR brachytherapy.
Erectile dysfunction (ED) is a recognized adverse effect of focal ablative therapy, although the mechanistic basis to the effects of such treatments on erectile function is largely unknown, with both neuropathic and vascular factors implicated. We aimed to evaluate the determinants of ED following focal ablative therapy using HIFU.
To determine if PSA kinetics following focal high-intensity focused ultrasound (HIFU) for the treatment of non-metastatic prostate cancer can predict treatment failure.
The proportion of men with return to baseline genitourinary function after prostate cancer treatment is a poorly reported metric. We assessed return to baseline function and pre-operative factors that might be associated with post-operative incontinence, erectile dysfunction or change in International Prostate Symptoms Score (IPSS) after focal HIFU.
To determine if delivering greater amounts of focused Ultrasound heat energy when treating non-metastatic prostate cancer using focal HIFU leads to lower recurrence rates.
CONCLUSION: High-intensity focused ultrasound appears to be a safe alternative for the treatment of localised prostate cancer, especially for low-risk localised prostate cancer. In our experience, this technique offers advantages in preserving urinary continence, and the medium-term oncological results are encouraging. Given the natural progression of prostate cancer, long-term studies with a larger number of cases are needed to corroborate these results. PMID: 29573835 [PubMed - as supplied by publisher]