[Pharmacokinetics and pharmacodynamics of antibiotic therapy.]

[Pharmacokinetics and pharmacodynamics of antibiotic therapy.]
Anaesthesist. 2014 Aug 24;
Authors: Beck S, Wicha SG, Kloft C, Kees MG
Abstract
Antibiotic agents are crucial pillars in intensive care medicine and must be used rationally and sensibly. In the case of critically ill patients optimal dosing with respect to pharmacokinetic and pharmacodynamic principles (PK/PD) can be vital. Preclinical results demonstrated important differences between antibiotic classes and gave rise to differing clinical dosing strategies, e.g. high dose once daily regimens for aminoglycosides or extended/continuous infusion of betalactams. Critically ill patients with altered pharmacokinetic parameters and infections by pathogens with low susceptibility are most likely to benefit from PK/PD-guided therapy.
PMID: 25150263 [PubMed - as supplied by publisher]

Source: Der Anaesthesist - August 24, 2014 Category: Anesthesiology Authors: Beck S, Wicha SG, Kloft C, Kees MG Tags: Anaesthesist Source Type: research