Crinane, augustamine, and β-carboline alkaloids from Crinum latifolium

Publication date: April 2018 Source:Phytochemistry Letters, Volume 24 Author(s): Tran Thi Hong Hanh, Do Hoang Anh, Phan Thi Thanh Huong, Nguyen Van Thanh, Nguyen Quang Trung, Tran Van Cuong, Nguyen Thi Mai, Nguyen The Cuong, Nguyen Xuan Cuong, Nguyen Hoai Nam, Chau Van Minh Three new crinane-type alkaloids, namely, 6-methoxyundulatine (1), 6-methoxycrinamidine (2), and undulatine N-oxide (3), along with the known compounds 6-hydroxyundulatine (4), 6-hydroxybuphanidrine (5), undulatine (6), crinamidine (7), ambelline (8), filifoline (9), augustamine (10), and perlolyrine (11), were isolated from the leaves of Crinum latifolium by using various chromatographic separations. Their structures were established by extensive analysis, including 1D and 2D NMR, HR-QTOF-MS, and CD data. Among the isolated compounds, perlolyrine (11) showed significant cytotoxicity against five human cancer cell lines, namely, KB, HepG2, MCF7, SK-Mel2, and LNCaP with the IC50 values ranging from 22.12 ± 2.80 to 28.45 ± 3.75 μM. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research