Integrated Analysis of HER2 Copy Number by Cytogenomic Microarray in Breast Cancers With Nonclassical In Situ Hybridization Results.

Conclusions: CMA can be helpful for clarifying HER2 amplification status in breast cancer. However, uncertainties over tumor percentage, clonal heterogeneity, and varying ploidy levels present challenges for genomic methods such as CMA. Accurate interpretation of HER2 copy number by CMA requires correlation with the pathology and ISH data. PMID: 29385416 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/29385416?dopt=Abstract

Source: Clinical Genitourinary Cancer - January 29, 2018 Category: Cancer & Oncology Authors: Haskell GT, Liu YJ, Chen H, Chen B, Meyer RG, Yuhas JA, Geiersbach KB Tags: Am J Clin Pathol Source Type: research