Why Do Physicians Overtreat Elderly Breast Cancer Patients? Why Do Physicians Overtreat Elderly Breast Cancer Patients?
Drs Kathy Miller and Reshma Jagsi on the reasons behind practitioners'reluctance to omit radiation therapy in older patients.Medscape Oncology
Abstract PURPOSE: The occurrence of upper extremity lymphedema after regional nodal irradiation (RNI) for breast cancer treatment varies significantly based on patient and treatment factors. The relationship between the radiation therapy (RT) field design and lymphedema risk is not well-characterized. The present study sought to correlate the variations in RT field design with lymphedema outcomes. METHODS AND MATERIALS: Women with stage II-IV breast cancer receiving RNI after breast surgery that included sentinel lymph node biopsy or axillary dissection were identified. Their arm circumference was measured be...
Researchers have found that radiation therapy after lumpectomy in women with...Read more on AuntMinnie.comRelated Reading: Microbubbles improve breast cancer radiation therapy ASTRO: Short radiation course safe for breast cancer LED device could predict skin damage from breast RT Robotic IMRT-APBI works well for breast cancer patients SABCS: Study links APBI to higher complication rates
Conditions: Anatomic Stage I Breast Cancer AJCC v8; Anatomic Stage IA Breast Cancer AJCC v8; Anatomic Stage IB Breast Cancer AJCC v8; Anatomic Stage IIA Breast Cancer AJCC v8; Prognostic Stage I Breast Cancer AJCC v8; Prognostic Stage IA Breast Cancer AJCC v8; Prognostic Stage IB Breast Cancer AJCC v8; Prognostic Stage IIA Breast Cancer ...
(JAMA Network) Lumpectomy plus radiation was associated with a small clinical benefit in reduced risk of breast cancer death compared with lumpectomy or mastectomy alone in women with ductal carcinoma in situ (DCIS), a noninvasive early form of breast cancer.
Improvements in cancer survivorship have led to increased recognition of treatment-related toxicities, some of which may not occur until years after the conclusion of treatment (1, 2). For breast cancer survivors, lymphedema is one of the most dreaded complications of surgery, radiation therapy, and taxane-based chemotherapy. Lymphedema involves a build-up of extracellular fluid within the upper extremity and results in swelling and, at times, chronic skin changes, fibrosis, loss of sensation, deformity, and pain (3).
This patient presents with stage IV, cT4dN3cM1 oligometastatic inflammatory breast cancer (IBC) (1). The initial treatment would be neoadjuvant chemotherapy (NAC). In the absence of progression with NAC, we would recommend mastectomy with axillary lymph node dissection and postmastectomy radiation therapy (PMRT). Given IBC's penchant for locoregional recurrence and progression to carcinoma en cuirasse, an aggressive approach to PMRT is warranted, despite the presence of initial limited metastatic disease.
Abstract BMI-1 (B-lymphoma Mo-MLV insertion region 1) is a key protein partner in polycomb repressive complex 1 (PRC1) that helps in maintaining the integrity of the complex. It is also a key player in ubiquitination of histone H2A which affects gene expression pattern involved in various cellular processes such as cell proliferation, growth, DNA repair, apoptosis and senescence. In many cancers, Overexpression of BMI1correlates with advanced stages of disease, aggressive clinicopathological behavior, poor prognosis resistance to radiation and chemotherapy. BMI1 is emerging as a key player in EMT, chemo-resistance...
Internal mammary chain radiation therapy for breast cancer is associated with increased cardiac toxicity, in particular when paired with anthracyclines.
We present our clinical experience with DIBH in left breast and chest-wall irradiation using 3D optical surface tracking.