Intestinal Microbiota Injury during Allo-Hct is Generalizable across Transplantation Centers and is Associated with Increased Mortality, Broad-Spectrum Antibiotics, and Decreased Calorie Intake

Intestinal microbiota composition is associated with important outcomes after allo-HCT including survival, relapse, GVHD, and infections. Loss of diversity after allo-HCT and domination by single organisms is common. Low diversity is associated with poor overall survival from transplant-related mortality, including death after GVHD. These observations were all made in single-center cohorts. Here we compare —for the first time—the kinetics of microbiota diversity in allo-HSCT patients (pts) from three independent international institutions.

Source: Biology of Blood and Marrow Transplantation - February 1, 2018 Category: Hematology Authors: Jonathan U. Peled, Antonio Gomes, Marissa Lubin Buchan, Christoph Stein-Thoeringer, John Slingerland, Ann E. Slingerland, Daniela Weber, Anthony D. Sung, Molly Maloy, Tatanisha Peets, Boglarka Gyurkocza, Sergio A. Giralt, Robert R. Jenq, Ying Taur, Joao X Source Type: research