Regulation of Hippo Signaling by Actin Remodeling.

Regulation of Hippo Signaling by Actin Remodeling.
BMB Rep. 2018 Jan 22;:
Authors: Seo J, Kim J
Abstract
The Hippo signaling pathway controls nuclear accumulation and stability of the transcriptional coregulator YAP and its paralog TAZ. The activity of Hippo-YAP signaling is influenced not only by biochemical signals, but also by cell shape and mechanical tension transmitted through cell-cell junctions and cell-matrix adhesions. Data accumulated thus far indicates that the actin cytoskeleton is a key mediator of the regulation of Hippo-YAP signaling by means of a variety of biochemical and mechanical cues. In this review, we have outlined the role of actin dynamics and actin-associated proteins in the regulation of Hippo-YAP signaling. In addition, we discuss actin-mediated regulation of YAP/TAZ activity independent of the core Hippo kinases MST and LATS. Although our understanding of the link between Hippo-YAP signaling and the actin cytoskeleton is progressing rapidly, many open questions remain.
PMID: 29353600 [PubMed - as supplied by publisher]

Source: BMB Reports - January 22, 2018 Category: Biochemistry Authors: Seo J, Kim J Tags: BMB Rep Source Type: research