Mechanisms of enhanced osteoclastogenesis in Alkaptonuria.

In conclusion, the altered osteoclastogenesis was observed already in AKU children despite the absence of evident injury. Thus, a preventive approach in young patients, targeting osteoclast activity, may prevent the macroscopic bone disease which appears in adult AKU.
PMID: 29353057 [PubMed - as supplied by publisher]

Source: The American Journal of Pathology - January 15, 2018 Category: Pathology Authors: Brunetti G, Tummolo A, D'Amato G, Gaeta A, Ortolani F, Piacente L, Giordano P, Colucci S, Grano M, Papadia F, Faienza MF Tags: Am J Pathol Source Type: research