Basophils from allergic patients are neither hyper-responsive to activation signals nor hypo-responsive to inhibition signals

Basophils from allergic patients are neither hyper-responsive to IgE-induced activation nor hypo-responsive to IgG- and/or lactobacilli-induced inhibition. Mechanisms that control basophil activation can therefore be used as therapeutic tools in allergic diseases.

Source: Journal of Allergy and Clinical Immunology - January 21, 2018 Category: Allergy & Immunology Authors: Lydie Cassard, Katia Sperber, Tan-Phuc Buivan, Aur élie Cotillard, Raphaëlle Bourdet-Sicard, Matthew L. Albert, Estelle Mottez, Jérôme Laurent, Marie-Thérèse Guinnepain, Marc Daëron Source Type: research