Clearance of serum solutes by hemofiltration in dogs with severe heat stroke

Background: We have previously reported that hemofiltration (HF) may be an effective additional means of treating heat stroke when rapid cooling is not effective. Methods: Dogs were assigned to a heat stroke (control) or heat stroke?+?hemofiltration (HF) group (n?=?8 each group). After heat stroke induction, dogs in the HF group received HF for 3?h. Serum concentrations of interleukin (IL)-10, tumor necrosis factor (TNF)-?, IL-6, blood urea nitrogen (BUN) and creatinine were measured at baseline and 1, 2, and 3?h after heat stroke. Clearance rates of solutes were determined 1, 2, and 3?h after the start of HF. Results: Serum concentrations of all solutes tended to increase with time after heat stroke in the control group, but decreased (BUN, creatinine) or remained relatively unchanged (TNF-?, IL-6, IL-10) with time in the HF group. Concentrations of all solutes were significantly lower in the HF group compared with the control group at 2 and 3?h (P?
Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research