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US OKs 1st drug aimed at women with inherited breast cancer

U.S. regulators have approved the first drug aimed at breast cancer patients who have an inherited mutation in the BRCA gene
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news

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In this study, a surface functionalized magnetic nanocomposite (NC) for codelivery of doxorubicin (DOX) and curcumin (CUR) is developed. NCs were coated with hydroxyapatite and were also cross linked with β-cyclodextrin. NCs efficiently encapsulated DOX and CUR. Release of CUR and DOX were in a sustained pH-depended pattern. β-cyclodextrin functionalization reduced protein corona according sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) analysis. As shown by flowcytometric and confocal microscopy analyses, NCs internalized efficiently by human breast carcinoma cells MCF-7 and adriamycin resis...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
ConclusionsBreast cancer survivors with atrophy-related complaints after pelvic floor surgery may benefit from vaginal application of this innovative dual protocol of Er:YAG laser technology as a non-hormonal treatment approach.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsBRCA1 mutation testing may be useful in clinically sporadic breast cancer patients with medullary features to identify potential mutation carriers independently from intrinsic molecular subtype. Formalin-fixed paraffin-embedded cancer tissue can undergo testing within a routine molecular-diagnostic setting as a clinicalBRCA1/2 mutation screening strategy.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Epigenetic changes may help explain racial disparities in estrogen receptor (ER)-negative breast cancer, say researchers from Roswell Park Comprehensive Cancer Center in Buffalo, New York.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news
Use of estrogen-alone hormone replacement therapy (HRT) after oophorectomy does not increase the risk of BRCA 1-associated breast cancer, although this may not be the case for progesterone-continuing HRT, researchers say.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news
Pfizer Inc said on Monday U.S. regulators declined to approve the company ’ s biosimilar of Roche ’ s blockbuster treatment for breast cancer, Herceptin, and sought additional technical information.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Pharmacist News Source Type: news
Conclusion: The results are controversial. However, they arouse a great interest in the potential participation of HPV in breast carcinogenesis, but rather as an essential cause-effect participant, at least as a co-participant in some cases. The circumstance of HPV positivity in breast cancer can be criticized, but the elements that clearly demonstrate it in a number of cases are also relevant.Acta Cytologica
Source: Acta Cytologica - Category: Cytology Source Type: research
When Dr. Anne Peled, a 37-year-old breast cancer surgeon and mother of three, was struck by the same cancer as her patients, her world changed.
Source: ABC News: Health - Category: Consumer Health News Tags: GMA Source Type: news
Tips on making palliative care discussions a routine part of advanced breast cancer treatment.Medscape Oncology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Article Source Type: news
Authors: Choi J, Kim ES, Koo JS Abstract Purpose: The purpose of this study was to assess the expression of pentose phosphate pathway- (PPP-) related proteins and their significance in clinicopathologic factors of breast cancer. Methods: Immunohistochemical staining for PPP-related proteins (glucose-6-phosphate dehydrogenase [G6PDH], 6-phosphogluconolactonase [6PGL], 6-phosphogluconate dehydrogenase [6PGDH], and nuclear factor-erythroid 2-related factor 2 [NRF2]) was performed using tissue microarray (TMA) of 348 breast cancers. mRNA levels of these markers in publicly available data from the Cancer Genome Atla...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
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