US OKs 1st drug aimed at women with inherited breast cancer

U.S. regulators have approved the first drug aimed at breast cancer patients who have an inherited mutation in the BRCA gene
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news

Related Links:

BREAST cancer risk could be lowered by making some diet changes, scientists have revealed. This is how many fruit and vegetables you should eat every day to lower the risk of breast cancer symptoms.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Can CTCs be used to predict prognosis and response to neoadjuvant chemotherapy in nonmetastatic breast cancer?Journal of the National Cancer Institute
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news
Publication date: October 2018Source: Biomedicine &Pharmacotherapy, Volume 106Author(s): Kamal Ahmad, Zubair Bin Hafeez, Abdul Roof Bhat, Moshahid Alam Rizvi, Sonu C. Thakur, Amir Azam, Fareeda AtharAbstractCallistemon lanceolatus (Myrtaceae) has been utilized in folk medicine and its pharmacological properties are widely studied. Phytochemicals are effectively recognized as bases of pharmacologically potent drugs for the development of anticancer therapeutics. The free radical scavenging potential of numerous extracts of C. lanceolatus leaves, Hexane leaf extract (HLE), Chloroform leaf extract (CLE), Ethyl acetate lea...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Regulation of the interferon-gamma (IFN-γ) pathway by p63 and Δ133p53 isoform in different breast cancer subtypes. Oncotarget. 2018 Jun 26;9(49):29146-29161 Authors: Mehta SY, Morten BC, Antony J, Henderson L, Lasham A, Campbell H, Cunliffe H, Horsfield JA, Reddel RR, Avery-Kiejda KA, Print CG, Braithwaite AW Abstract The TP53 family consists of three sets of transcription factor genes, TP53, TP63 and TP73, each of which expresses multiple RNA variants and protein isoforms. Of these, TP53 is mutated in 25-30% of breast cancers. How TP53 mutations affect the interaction of TP53 family member...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Ferraz da Costa DC, Campos NPC, Santos RA, Guedes-da-Silva FH, Martins-Dinis MMDC, Zanphorlin L, Ramos C, Rangel LP, Silva JL Abstract One potential target for cancer therapeutics is the tumor suppressor p53, which is mutated in more than 50% of malignant tumors. Loss of function (LoF), dominant negative (DN) and gain of function (GoF) mutations in p53 are associated with amyloid aggregation. We tested the potential of resveratrol, a naturally occurring polyphenol, to interact and prevent the aggregation of wild-type and mutant p53 in vitro using fluorescence spectroscopy techniques and in human breast can...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Cancemi P, Buttacavoli M, Di Cara G, Albanese NN, Bivona S, Pucci-Minafra I, Feo S Abstract The S100 gene family is the largest subfamily of calcium binding proteins of EF-hand type, expressed in tissue and cell-specific manner, acting both as intracellular regulators and extracellular mediators. There is a growing interest in the S100 proteins and their relationships with different cancers because of their involvement in a variety of biological events closely related to tumorigenesis and cancer progression. However, the collective role and the possible coordination of this group of proteins, as well as th...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
We presented the first study utilizing both conventional and new analytics including ensemble method and predictive modeling based on smallest errors to predict BC risks. Predictive modeling of Generalized Regression Elastic Net Leave-One-Out demonstrated alcohol use (p = 0.0126) and age (p
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Publication date: Available online 19 July 2018Source: Life SciencesAuthor(s): Yawei Shi, Yang Zhao, Yunjian Zhang, NiJiati AiErken, Nan Shao, Runyi Ye, Ying Lin, Shenming WangAbstractAimsBreast cancer is the major diagnosed cancer and the leading reason of cancer related death among women, and the tumor size is one of the risk factors. Therefore, it is significant to reveal the principle of breaking the subtle homeostasis of cell cycle and sustaining chronic proliferation of cancer cells.Main methodsThe expression of TNNT1 was examined by qPCR and western blotting. The effect of TNNT1 on cell proliferation was detected by...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: 10 November 2018Source: Sensors and Actuators B: Chemical, Volume 273Author(s): Shuangshuang Wu, Changhui Chen, Haitang Yang, Wei Wei, Min Wei, Yuanjian Zhang, Songqin LiuAbstractPoly(ADP-ribose) polymerase-1 (PARP-1) monitoring has attracted extensive attention because it serves a vital role in human pathologies. However, only a few researches about its detection methods have been reported because PARP-1 and its catalyzed product poly(ADP-ribose) polymer (PAR) are lack of optical or electrochemical activity. Herein, a convenient fluorescence “turn-off-on” nanosensor based on cationic conjugat...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: 10 November 2018Source: Sensors and Actuators B: Chemical, Volume 273Author(s): João G. Pacheco, Patrícia Rebelo, Maria Freitas, Henri P.A. Nouws, Cristina Delerue-MatosAbstractThe extracellular domain of the human epidermal growth factor receptor 2 (HER2-ECD) is a protein breast cancer biomarker. Its quantification in peripheral blood could provide an important contribution to diagnostics and patient follow-up. In this work an electrochemical molecularly imprinted polymer (MIP) sensor for the quantification of HER2-ECD was developed. The MIP was electropolymerized by cyclic voltammetry usin...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
More News: Breast Cancer | Cancer | Cancer & Oncology | Genetics | Health | Women