US OKs 1st drug aimed at women with inherited breast cancer
U.S. regulators have approved the first drug aimed at breast cancer patients who have an inherited mutation in the BRCA gene
In this study, a surface functionalized magnetic nanocomposite (NC) for codelivery of doxorubicin (DOX) and curcumin (CUR) is developed. NCs were coated with hydroxyapatite and were also cross linked with β-cyclodextrin. NCs efficiently encapsulated DOX and CUR. Release of CUR and DOX were in a sustained pH-depended pattern. β-cyclodextrin functionalization reduced protein corona according sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) analysis. As shown by flowcytometric and confocal microscopy analyses, NCs internalized efficiently by human breast carcinoma cells MCF-7 and adriamycin resis...
ConclusionsBreast cancer survivors with atrophy-related complaints after pelvic floor surgery may benefit from vaginal application of this innovative dual protocol of Er:YAG laser technology as a non-hormonal treatment approach.
ConclusionsBRCA1 mutation testing may be useful in clinically sporadic breast cancer patients with medullary features to identify potential mutation carriers independently from intrinsic molecular subtype. Formalin-fixed paraffin-embedded cancer tissue can undergo testing within a routine molecular-diagnostic setting as a clinicalBRCA1/2 mutation screening strategy.
Epigenetic changes may help explain racial disparities in estrogen receptor (ER)-negative breast cancer, say researchers from Roswell Park Comprehensive Cancer Center in Buffalo, New York.Reuters Health Information
Use of estrogen-alone hormone replacement therapy (HRT) after oophorectomy does not increase the risk of BRCA 1-associated breast cancer, although this may not be the case for progesterone-continuing HRT, researchers say.Reuters Health Information
Pfizer Inc said on Monday U.S. regulators declined to approve the company ’ s biosimilar of Roche ’ s blockbuster treatment for breast cancer, Herceptin, and sought additional technical information.Reuters Health Information
Conclusion: The results are controversial. However, they arouse a great interest in the potential participation of HPV in breast carcinogenesis, but rather as an essential cause-effect participant, at least as a co-participant in some cases. The circumstance of HPV positivity in breast cancer can be criticized, but the elements that clearly demonstrate it in a number of cases are also relevant.Acta Cytologica
When Dr. Anne Peled, a 37-year-old breast cancer surgeon and mother of three, was struck by the same cancer as her patients, her world changed.
Tips on making palliative care discussions a routine part of advanced breast cancer treatment.Medscape Oncology
Authors: Choi J, Kim ES, Koo JS Abstract Purpose: The purpose of this study was to assess the expression of pentose phosphate pathway- (PPP-) related proteins and their significance in clinicopathologic factors of breast cancer. Methods: Immunohistochemical staining for PPP-related proteins (glucose-6-phosphate dehydrogenase [G6PDH], 6-phosphogluconolactonase [6PGL], 6-phosphogluconate dehydrogenase [6PGDH], and nuclear factor-erythroid 2-related factor 2 [NRF2]) was performed using tissue microarray (TMA) of 348 breast cancers. mRNA levels of these markers in publicly available data from the Cancer Genome Atla...