Shaker ‐related voltage‐gated K+ channel expression and vasomotor function in human coronary resistance arteries

ConclusionsKV1.5, as a major 4‐AP‐sensitive KV1 channel expressed in coronary VSMCs, mediates cAMP‐mediated dilation in non‐CAD arterioles. The cAMP‐mediated dilation is reduced in CAD coronary arterioles, which is associated with impaired 4‐AP‐sensitive KV channel function.

Source: Microcirculation - January 9, 2018 Category: Research Authors: Yoshinori Nishijima, Ankush Korishettar, Dawid S. Chabowski, Sheng Cao, Xiaodong Zheng, David D. Gutterman, David X. Zhang Tags: ORIGINAL ARTICLE Source Type: research